Institute of Chemical Physics

    Development of techniques which can intensify regenerative processes in the body is one of important approaches of the contemporary personalized medicine aimed at the repair of the lost tissues’ structure and functionality. To successfully achieve that goal, synthetic biocompatible materials may be used which make a basis for carrier matrices (scaffolds) with several functions in the tissue regeneration.First of all, such scaffolds create a supporting frame, at the same time being a carrier of autologous cells and substances which intensify cell proliferation and differentiation. The modern biomedical materials science is an interdisciplinary field of research, including a chemical (synthesis of new substances, functionalization of new materials’surface), physical (materials structuring, their characterization and visualization) and a biological (evaluation of biocompatibility) directions of studies.

The main mission of the Department of Modern Biomaterials is the development of approaches to creation of biocompatible carrier matrices based on modern chemical technology and 3D printing, as well as the development of the ways to improve the artificial materials’ compatibility with living systems and the ways of intensification of regenerative processes. A crucial requirement to the cell carrier matrix is a possibility of its destruction in vivo, which should lead to the total desorption of the artificial material when the regeneration is completed. At the same time, the rate of the matrix degradation should correspond to the rate of a new tissue growth, to provide the highest efficiency of the regenerative process. Degradation of a cell carrier matrix in vivo is a complex multifactorial process, the rate of which is determined both by the surrounding tissue and by theproperties of the matrix itself: its chemical composition, molecular weight and polydispersity; presence of low-molecular components and ionic groups; morphology (crystallinity); techniques and parameters of its structuring; sterilization technique; physico-chemical factors (size,shape) and a number of others. The studies within the Department are directed towards the solution of fundamental problems of the modern biomedical materials science and include applied research in the field of creation and functionalization of materials for regenerative medicine.
For the successful realization of the set goals, the Department of Modern Biomaterials performs collaborated studies with leading Russian and foreign research institutes:

- Institute of photonic technologies, Federal Scientific Research Center
- “Crystallography and Photonics” of RAS (Troitsk, Moscow)
- Institute of Chemical Physics (Moscow)
- Baikal Institute of Nature Management, Siberian Branch of RAS (Ulan-Ude)
- Hannover Lazer Zentrum (Hannover, Germany)
- National University of Ireland (Galway, Ireland)