30.08.2018 16:30 - 30.08.2018

Lecture by Prof Raymond Cespuglio

Lecture title: “Serotonin: its place today in sleep preparation, triggering and maintenance”The lecture will be held on August 30, 2018 (Friday) at 4.30 p.m. in the Big Lecture Hall, Department of Normal Physiology (Mohovaya str., 11/4)


Prof Raymond Cespuglio is a Director of Research INSERM, 1st class, at his emeritus position at the Neuroscience Center of Lyon (CRNL) Claude Bernard University of Lyon. Recently he has joined (part-time) the Laboratory of Psychiatric Neurobiology, Institute for Molecular Medicine, Sechenov University, Russia. He was the first successor (1998-2003) of Professor Michel Jouvet the discoverer of paradoxical sleep state (REM sleep) and led sleep research in his laboratory for over 30 years. From 2014 to 2017, he taught (part-time) the human anatomy to students in China (Guangzhou University). 


Prof R. Cespuglio has made sound contribution in understanding of sleep mechanisms, over decades studying its physiology, biochemistry and associated metabolic processes.
In particular, his laboratory has obtained new important data on the relationships between regulation of stress and neurobiology of sleep. One of his main findings concern the demonstration of the phenomenon of sleep rebound induced by chronic uncontrolled situation of stress, in experimental animals that show an unbalanced sleep compensation. E.g., changes in rapid eye movement sleep (REM sleep), when lasting, can be associated with various pathological situations and be associated with brain disorders including depression. Besides, Prof. Cespuglio has contributed to the current knowledge of the pathophysiology of sleep abnormalities during infectious diseases, particularly, sleeping sickness and malaria. Part of the research activities of Prof R. Cespuglio was devoted to the development of biosensors for direct brain measurement of biochemical species (Nitric oxide, glucose, lactate, D-serine, etc.) using voltammetry. 


Finally, Prof. R. Cespuglio is the author of about 300 publications (H index 43) and contributed to large number of PhD projects, education and research projects of young researchers, organization of scientific meetings at local and international level, book publication.