ROLE OF ORGANISM REACTIVITY AND MUCOSAL IMMUNITY IN MODULATING OF PATHOGENICITY AND VIRULENCE OF OPPORTUNISTIC MICROFLORA IN DYNAMICS OF INFECTIOUS PROCESS AND ALSO IN MACROAND MICROORGANISMS GENE POOLS MAINTENANCE (Роль реактивности организма и мукозальн
|
|
Караулов Александр Викторович
Афанасьев Максим Станиславович
Несвижский Юрий Владимирович
|
Инфекционные болезни |
|
|
The review is summarizing for the first time the results of original research and literature data revealing the conditions of opportunistic microflora (OM) pathogenicity and virulence formation in the dynamics of the infectious process, as well as maintenance and formation of gene pools in host cells and microorganisms. It is established, that formation or loss of pathogenic and virulent properties of microorganisms in the body happens under the influence of its external environment, its overall physiological and immunological reactivity, mucosal immunity, as well as with the direct participation of horizontal gene transfer. Newly created microbial pathogens cause infectious-inflammatory diseases. However, acquired pathogenicity factors are lost after recovery. Plasticity of gene pools of the macroorganism and microorganisms allows owners of gene pools to respond adequately to changes in the external and internal body environment, improve and enhance overall and immunological reactivity of the macroorganism in ontogenesis, generate optimal for specific situations symbiotic or antagonistic relationships between them taking into account newly acquired or lost pathogenicity and virulence factors and form new phenotypic or genetic properties of microorganisms. Horizontal genetic transfer is the process of moving the genetic information which is possible between prokaryotic and eukaryotic cells both ways, as well as within a single cell.
Читать
тезис
Публикация |
Recombination in the rabies virus and other lyssaviruses
|
|
Девяткин Андрей Андреевич
Лукашев Александр Николаевич
|
Infection, Genetics and Evolution |
|
|
Recombination is a common event in RNA viruses; however, in the rabies virus there have been only a few reports of isolated recombination events. Comprehensive analysis found traces of recent recombination events within Arctic, Arctic-like and Africa 1b rabies virus groups, as well as recombination between distinct lyssaviruses. Recombination breakpoints were not linked to gene boundaries and could be detected all over the genome. However, there was no evidence that recombination is an important factor in the genetic variability of the rabies virus. It is therefore likely that recombination in the rabies virus is limited by ecological factors (e.g., rare co-circulation of distinguishable lineages and a narrow window for productive coinfection in most carnivore hosts), rather than molecular barriers (e.g., incompatibility of genome fragments).
Читать
тезис
Публикация |
Mesenchymal Stem Cell Therapy For Ischemic Heart Disease: Advances And Challenges
|
|
Коноплянников Михаил Анатольевич
Котова Светлана Леонидовна
|
Current Pharmaceutical Design |
|
|
Ischemic Heart Disease (IHD) has been recognized as the main cause of mortality in the modern world. Application of cell therapy technologies for the IHD treatment has been actively studied from the beginning of 2000s. The review is dedicated to the use of mesenchymal stem cells (MSC) in the therapy of IHD. The strategies of the MSC modification in vitro for improvement of their regenerative potential are extensively discussed, including preconditioning to enhance the cell survival, boosting their paracrine effect and manipulating their cardiomyogenic differentiation. The optimization of the MSC delivery and opportunities related to the use of biomaterials as cell carriers are also discussed. The results of the most important clinical studies on the MSC-based IHD therapy are presented, including those completed and published in the literature and the ongoing clinical trials registered at clinicaltrials.gov by June 2018.
Читать
тезис
Публикация |
ROLE OF ORGANISM REACTIVITY AND MUCOSAL IMMUNITY IN MODULATING OF PATHOGENICITY AND VIRULENCE OF OPPORTUNISTIC MICROFLORA IN DYNAMICS OF INFECTIOUS PROCESS AND ALSO IN MACROAND MICROORGANISMS GENE POOLS MAINTENANCE (Роль реактивности организма и мукозальн
|
|
Караулов Александр Викторович (Заведующий кафедрой)
Афанасьев Максим Станиславович (Профессор)
Несвижский Юрий Владимирович (Профессор)
|
Инфекционные болезни |
|
|
The review is summarizing for the first time the results of original research and literature data revealing the conditions of opportunistic microflora (OM) pathogenicity and virulence formation in the dynamics of the infectious process, as well as maintenance and formation of gene pools in host cells and microorganisms. It is established, that formation or loss of pathogenic and virulent properties of microorganisms in the body happens under the influence of its external environment, its overall physiological and immunological reactivity, mucosal immunity, as well as with the direct participation of horizontal gene transfer. Newly created microbial pathogens cause infectious-inflammatory diseases. However, acquired pathogenicity factors are lost after recovery. Plasticity of gene pools of the macroorganism and microorganisms allows owners of gene pools to respond adequately to changes in the external and internal body environment, improve and enhance overall and immunological reactivity of the macroorganism in ontogenesis, generate optimal for specific situations symbiotic or antagonistic relationships between them taking into account newly acquired or lost pathogenicity and virulence factors and form new phenotypic or genetic properties of microorganisms. Horizontal genetic transfer is the process of moving the genetic information which is possible between prokaryotic and eukaryotic cells both ways, as well as within a single cell.
Читать
тезис
Публикация |
Recombination in the rabies virus and other lyssaviruses
|
|
Девяткин Андрей Андреевич (старший научный сотрудник, лаборатория молекулярной биохимии)
Лукашев Александр Николаевич (Директор ФГБНУ ИПВЭ им.М.П.Чумакова, зав.лаб, НИИМПиТМ им.Е.И.Марциновского, Первого МГМУ им. И.М.Сеченова в.н.с.)
|
Infection, Genetics and Evolution |
|
|
Recombination is a common event in RNA viruses; however, in the rabies virus there have been only a few reports of isolated recombination events. Comprehensive analysis found traces of recent recombination events within Arctic, Arctic-like and Africa 1b rabies virus groups, as well as recombination between distinct lyssaviruses. Recombination breakpoints were not linked to gene boundaries and could be detected all over the genome. However, there was no evidence that recombination is an important factor in the genetic variability of the rabies virus. It is therefore likely that recombination in the rabies virus is limited by ecological factors (e.g., rare co-circulation of distinguishable lineages and a narrow window for productive coinfection in most carnivore hosts), rather than molecular barriers (e.g., incompatibility of genome fragments).
Читать
тезис
Публикация |
Mesenchymal Stem Cell Therapy For Ischemic Heart Disease: Advances And Challenges
|
|
Коноплянников Михаил Анатольевич (ведущий научный сотрудник)
Котова Светлана Леонидовна (старший научный сотрудник)
|
Current Pharmaceutical Design |
|
|
Ischemic Heart Disease (IHD) has been recognized as the main cause of mortality in the modern world. Application of cell therapy technologies for the IHD treatment has been actively studied from the beginning of 2000s. The review is dedicated to the use of mesenchymal stem cells (MSC) in the therapy of IHD. The strategies of the MSC modification in vitro for improvement of their regenerative potential are extensively discussed, including preconditioning to enhance the cell survival, boosting their paracrine effect and manipulating their cardiomyogenic differentiation. The optimization of the MSC delivery and opportunities related to the use of biomaterials as cell carriers are also discussed. The results of the most important clinical studies on the MSC-based IHD therapy are presented, including those completed and published in the literature and the ongoing clinical trials registered at clinicaltrials.gov by June 2018.
Читать
тезис
Публикация |
Type 3 Diabetes Mellitus: A Novel Implication of Alzheimers Disease
|
|
Тарасов В. В. (Директор)
Баранова А.М. (Ведущий научный сотрудник)
Несвижский Юрий Владимирович (Профессор)
|
CURRENT TOPICS IN MEDICINAL CHEMISTRY |
|
|
Background: The vascular endothelial growth factor (VEGF) is a neuroprotective cytokine that promotes neurogenesis and angiogenesis in the brain. In animal models, it has been shown that environmental enrichment and exercise, two non-pharmacological interventions that are beneficial decreasing the progression of Alzheimer disease (AD) and depressive-like behavior, enhance hippocampal VEGF expression and neurogenesis. Furthermore, the stimulation of VEGF expression promotes neurotransmission and synaptic plasticity processes such as neurogenesis. It is thought that these VEGF actions in the brain, may underly its beneficial therapeutic effects against psychiatric and other neurological conditions.
Conclusion: In this review, evidence linking VEGF deficit with the development of AD as well as the potential role of VEGF signaling as a therapeutic target for cotinine and other interventions in neurodegenerative conditions are discussed.
Читать
тезис
Публикация |
Native and Activated Hepatic Stellate Cells Stimulate Liver Regeneration in Rats After Partial Hepatectomy and 2-Acetylaminofluorene Injection
|
|
Шахмарданова С.А. (Доцент)
Замятнин А. А. (Директор)
Несвижский Юрий Владимирович (Профессор)
|
BioNanoScience |
|
|
One the current challenges of modern hepatology is to find new approaches to stimulate liver regeneration and to find new methods for liver disease treatment. Cell therapies, which are based on using regional stem cells for disease treatment, are under active development. However, studies, devoted to their transplantation, are currently scarce. In recent years, hepatic stellate cells are considered to be hepatic stem cells. It is known that activated hepatic stellate cells can transdifferentiate into myofibroblasts and lead to liver fibrosis. The aim of our work was to study the influence of native and activated hepatic stellate cells in vivo by lead nitrate injection after transplantation into partial hepatectomized rats, which is considered to be a classical model to study liver regeneration. Injection of 2-acetylaminofluorene (AAF), which selectively eliminates hepatocyte proliferation, was used to understand the hepatic stellate cells role in liver regeneration process better. Our results suggest that transplanted native and activated hepatic stellate cells can differentiate into hepatocyte-like cells and positively influence liver regeneration without inducing liver fibrosis.
Читать
тезис
Публикация |