Научная работа
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Научная работа

Основными направлениями научно-исследовательской работы кафедры являются:

  • Изучение проблемы диагностики и лечения различных фенотипов и тяжелых форм бронхообструктивных заболеваний
  • Изучение и ведение регистров интерстициальных и редких генетически детерминированных заболеваний легких;
  • Диагностика, оценка эффективности и безопасности новых лекарственных препаратов у пациентов с легочной гипертензией;
  • Разработка и внедрение в клиническую практику новых инструментальных методов исследования при болезнях органов дыхания

·         изучение механики дыхания, газообмена, стратегии и тактики респираторной поддержки у пациентов формами хронических заболеваний органов дыханияи дыхательной недостаточностью

В условиях пандемии COVID-19 сотрудниками кафедры был инициирован и в настоящее время проводится ряд научных исследований по диагностике и лечению пациентов с новой коронавирусной инфекцией:

·         Изучение эффективности различных ингаляционных препаратов в лечении тяжелых форм COVID-19

·         Биологическая терапия при COVID-19: клиническая эффективность и профиль безопасности различных таргетных антицитокиновых препаратов, предикторы их эффективности

·         Исследование работы вспомогательных дыхательных мышц, диафрагшмальной дисфункции и паренхимы легких при использовании различных инструментальных методов в оценке клинического течения и прогноза при COVID-19

·         Изучение механики дыхания и газообмена, работы дыхательных мышц при неинвазивной и инвазивной респираторной поддержке у пациентов с COVID-19

·         Изучение риска развития острого легочного сердца, дисфункции правого желудочка, а также терапевтических возможностей их коррекции у пациентов с COVID-19


Публикации сотрудников кафедры за 2020-2021 в журналах первого квартиля (Q1) базы данных Web of Science и Scopus


Avdeev S.N., Nekludova G.V., Trushenko N.V. et al. Lung ultrasound can predict response to the prone position in awake non-intubated patients with COVID‑19 associated acute respiratory distress syndrome. Critical Care. 2021; 25(1): 35. DOI: 10.1186/s13054-021-03472-1.


Avdeev S.N., Nekludova G.V., Tsareva N.A. et al. Pain, Swelling and Blue Discoloration of Right Hand in a COVID-19 Patient. Annals of Emergency Medicine. 2021; 77(6): 650-657. DOI: 10.1016/j.annemergmed.2021.01.001.


Nekludova G., Avdeev S., Trushenko N. Lung ultrasound presentation of covid-19 patients: phenotypes and correlations—comment. Internal and Emergency Medicine. 2021; 16(5): 1417-1418. DOI: 10.1007/s11739-021-02777-x.


Avdeev S.N., Trushenko N.V., Chikina S.Y. et al. Beneficial effects of inhaled surfactant in patients with COVID-19-associated acute respiratory distress syndrome. Respiratory Medicine. 2021; Vol.185: 106489. DOI: 10.1016/j.rmed.2021.106489.


Avdeev S.N., Trushenko N.V., Tsareva N.A. et al. Anti-IL-17 monoclonal antibodies in hospitalized patients with severe COVID-19: A pilot study. Cytokine. 2021; Vol.146: 155627. DOI: 10.1016/j.cyto.2021.155627.


Tsareva N.A., Avdeev S.N., Kosanovic D. et al. Inhaled iloprost improves gas exchange in patients with COVID-19 and acute respiratory distress syndrome. Critical Care. 2021; 25(1): 258. DOI: 10.1186/s13054-021-03690-7


Avdeev S.N., Merzhoeva Z.M., Samsonova M.V. et al. A 61-Year-Old Woman With Insidious Dyspnea and Diffuse Cystic Lung Disease. Chest. 2021; 160(2): e199-e203. DOI: 10.1016/j.chest.2021.02.044.


Avdeev S.N., Yaroshetskiy A.I., Tsareva N.A. et al. Noninvasive ventilation for acute hypoxemic respiratory failure in patients with COVID-19. American Journal of Emergency Medicine. 2021; 39(January): 154-157. DOI: 10.1016/j.ajem.2020.09.075.


Avdeev S.N., Gaynitdinova V.V., Merzhoeva Z.M., Berikkhanov Z.G.-M. N-acetylcysteine for the treatment of COVID-19 among hospitalized patients. Journal of Infection. 2021; Vol.: -. DOI: 10.1016/j.jinf.2021.07.003.


Avdeev S., Moiseev S., Brovko M. et al. Low prevalence of bronchial asthma and chronic obstructive lung disease among intensive care unit patients with COVID-19. Allergy. 2020; 75(10): 2703-2704. DOI: 10.1111/all.14420.


Avdeev S.N., Yaroshetskiy A.I., Nuralieva G.S. Can We Reliably Predict the Failure of Noninvasive Ventilation in COVID-19–associated Acute Hypoxemic Respiratory Failure?. Annals of the American Thoracic Society. 2021; 18(9): 1594-1595. DOI: 10.1513/AnnalsATS.202101-047LE.


Avdeev S., Tsareva N., Nekludova G. Inhaled Treprostinil in Group 3 Pulmonary Hypertension. New England Journal of Medicine. 2021; 384(19): 1871-. DOI: 10.1056/NEJMc2103465.


Avdeev S.N., Vizel A.A., Abrosimov V.N. et al. Management of cough in patients with chronic obstructive pulmonary disease: Results of the multicenter randomized placebo-controlled clinical trial. International Journal of Chronic Obstructive Pulmonary Disease. 2021; Vol.16: 1243-1253. DOI: 10.2147/COPD.S292109.


Avdeev S.N., Nekludova G.V., Trushenko N.V. et al. Can lung ultrasound predict histologic pattern of lung injury in critically ill patients with COVID‑19?. Intensive Care Medicine. 2021; 47(5): 629-630. DOI: 10.1007/s00134-021-06372-8.


Nekludova G.V., Avdeev S.N., Tsareva N.A. et al. Using TAPSE (tricuspid annular plane systolic excursion) as a predictor of poor prognosis of COVID-19: is it enough?. International Journal of Infectious Diseases. 2021; Vol.107: 164-. DOI: 10.1016/j.ijid.2021.04.056.


Yaroshetskiy A.I., Avdeev S.N., Konanykhin V.D. Acute respiratory distress syndrome in COVID-19: Do all these patients definitely require intubation and mechanical ventilation?. American Journal of Respiratory and Critical Care Medicine. 2020; 202(10): 1480-1481. DOI: 10.1164/rccm.202007-2713LE


Valipour A., Avdeev S., Barczyk A. et al. Therapeutic success of tiotropium/olodaterol, measured using the clinical COPD questionnaire (CCQ), in routine clinical practice: A multinational non-interventional study. International Journal of Chronic Obstructive Pulmonary Disease. 2021; Vol.16: 615-628. DOI: 10.2147/COPD.S291920.


Moiseev S., Avdeev S., Brovko M. et al. Outcomes of intensive care unit patients with COVID-19: a nationwide analysis in Russia. Anaesthesia. 2021; 76(S3): 11-12. DOI: 10.1111/anae.15265.


Ignatova G.L., Avdeev S.N., Antonov V.N. Comparative effectiveness of pneumococcal vaccination with PPV23 and PCV13 in COPD patients over a 5-year follow-up cohort study. Scientific Reports. 2021; 11(1): 15948. DOI: 10.1038/s41598-021-95129-w.


Moiseev S., Avdeev S., Brovko M. et al. Is there a future for hydroxychloroquine/chloroquine in prevention of SARS-CoV-2 infection (COVID-19)?. Annals of the Rheumatic Diseases. 2021; 80(2): 217570. DOI: 10.1136/annrheumdis-2020-217570.


Moiseev S., Avdeev S., Brovko M. et al. Cancer in intensive care unit patients with COVID-19. Journal of Infection. 2020; 81(2): e124-e125. DOI: 10.1016/j.jinf.2020.05.053.


Moiseev S., Avdeev S., Tao E. et al. Neither earlier nor late tocilizumab improved outcomes in the intensive care unit patients with COVID-19 in a retrospective cohort study. Annals of the Rheumatic Diseases. 2020; Vol.: 219265. DOI: 10.1136/annrheumdis-2020-219265.


Sydykov A., Luitel H., Mamazhakypov A. et al. Genetic deficiency and pharmacological stabilization of mast cells ameliorate pressure overload-induced maladaptive right ventricular remodeling in mice. International Journal of Molecular Sciences. 2020; 21(23): 9099. DOI: 10.3390/ijms21239099.


Zarogoulidis P., Huang H., Chou J. et al. Thyroid cancer diagnosis with transdermal probe 22G U/S versus EBUS-convex probe TBNA-B 22G and 19G: pros and cons. Expert Review of Medical Devices. 2021; 18(2): 197-201. DOI: 10.1080/17434440.2021.1880891.


Zyryanov S.K., Avdeev S.N., Ivanov D.A. et al. Clinical and economic comparison of utilization of reslizumab, mepolizumab and benralizumab in the treatment of severe eosinophilic asthma. Терапевтический архив. 2021; 92(12): 172-179. DOI: 10.26442/00403660.2020.12.200494.


Zarogoulidis P., Christakidis V., Petridis D. et al. Connection between PD-L1 expression and standardized uptake value in NSCLC: an early prognostic treatment combination. Expert Review of Respiratory Medicine. 2021; 15(5): 675-679. DOI: 10.1080/17476348.2021.1859373.


Zarogoulidis P., Hohenforst-Schmidt W., Huang H. et al. Intratumoral treatment with chemotherapy and immunotherapy for NSCLC with EBUS-TBNA 19G. Journal of Cancer. 2021; 12(9): 2560-2569. DOI: 10.7150/JCA.55322.


Hadzic S., Wu C.-Y., Gredic M. et al. The effect of long-term doxycycline treatment in a mouse model of cigarette smoke-induced emphysema and pulmonary hypertension. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2021; 320(5): L903-L915. DOI: 10.1152/ajplung.00048.2021.


Munblit D., Nekliudov N.A., Bugaeva P. et al. Reply to Russo et al. Clinical Infectious Diseases. 2021; 72(12): E1159-E1160. DOI: 10.1093/cid/ciaa1746.


Munblit D., Nekliudov N.A., Bugaeva P. et al. Stop COVID Cohort: An Observational Study of 3480 Patients Admitted to the Sechenov University Hospital Network in Moscow City for Suspected Coronavirus Disease 2019 (COVID-19) Infection. Clinical Infectious Diseases. 2021; 73(1): 1-11. DOI: 10.1093/cid/ciaa1535.


Katopodi T., Petanidis S., Domvri K. et al. Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit. Scientific Reports. 2021; 11(1): 15455. DOI: 10.1038/s41598-021-94671-x.


Saraji A., Sydykov A., Schäfer K. et al. PINK1-mediated mitophagy contributes to pulmonary vascular remodeling in pulmonary hypertension. American Journal of Respiratory Cell and Molecular Biology. 2021; 65(2): 226-228. DOI: 10.1165/rcmb.2021-0082LE.


Munblit D., Bobkova P., Spiridonova E. et al. Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19. Clinical & Experimental Allergy. 2021; 51(9): 1107-1120. DOI: 10.1111/cea.13997.


Zarogoulidis P., Petridis D., Sapalidis K. et al. Lung cancer biopsies: Comparison between simple 22G, 22G upgraded and 21G needle for EBUS-TBNA. Journal of Cancer. 2020; 11(21): 6454-6459. DOI: 10.7150/jca.48691.


Mamazhakypov A., Weiß A., Zukunft S. et al. Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats. Pulmonary circulation. 2020; 10(4): -. DOI: 10.1177/2045894020947283.


Fomin V., Moiseev S., Yavorovskiy A. et al. Letter to the Editor: Virtual Care for Critically Ill Patients with COVID-19. Telemedicine Journal and e-Health. 2020; 26(11): 1326-1327. DOI: 10.1089/tmj.2020.0214.


Papi A., Avdeev S., Calverley P.M.A. et al. Use of mucolytics in COPD: A Delphi consensus study. Respiratory Medicine. 2020; Vol.175: 106190. DOI: 10.1016/j.rmed.2020.106190.


Anestakis D., Petanidis S., Domvri K. et al. Carboplatin chemoresistance is associated with CD11b+/Ly6C+ myeloid release and upregulation of TIGIT and LAG3/CD160 exhausted T cells. Molecular Immunology. 2020; Vol.118: 99-109. DOI: 10.1016/j.molimm.2019.11.008.


Petanidis S., Domvri K., Porpodis K. et al. Inhibition of kras-derived exosomes downregulates immunosuppressive BACH2/GATA-3 expression via RIP-3 dependent necroptosis and miR-146/miR-210 modulation. Biomedicine & Pharmacotherapy. 2020; Vol.122: 109461. DOI: 10.1016/j.biopha.2019.109461.


Hadzic S., Wu C.-Y., Avdeev S. et al. Lung epithelium damage in COPD – An unstoppable pathological event?. Cellular Signalling. 2020; Vol.68: 109540. DOI: 10.1016/j.cellsig.2020.109540.


Alexidis P., Karatzoglou S., Dragoumis D. et al. Late results of a randomized trial on the role of mild hypofractionated radiotherapy for the treatment of localized prostate cancer. Journal of Cancer. 2020; 11(5): 1008-1016. DOI: 10.7150/jca.37825.


Zarogoulidis P., Huang H., Yang M. et al. Pleurodesis and immunotherapy in NSCLC; Medical thoracoscopy or VATS?. Journal of Cancer. 2020; 11(6): 1606-1613. DOI: 10.7150/jca.40004.


Heitmeier T., Sydykov A., Lukas C. et al. Altered proteasome function in right ventricular hypertrophy. Cardiovascular Research. 2020; 116(2): 406-415. DOI: 10.1093/cvr/cvz103.


Domvri K., Petanidis S., Anestakis D. et al. Dual photothermal MDSCs-targeted immunotherapy inhibits lung immunosuppressive metastasis by enhancing T-cell recruitment. Nanoscale. 2020; 12(13): 7051-7062. DOI: 10.1039/d0nr00080a.


Kreuter M., Polke M., Walsh S.L.F. et al. Acute exacerbation of idiopathic pulmonary fibrosis: International survey and call for harmonisation. European Respiratory Journal. 2020; 55(4): 1901760. DOI: 10.1183/13993003.01760-2019.


Luitel H., Novoyatleva T., Sydykov A. et al. Yarsagumba is a promising therapeutic option for treatment of pulmonary hypertension due to the potent anti-proliferative and vasorelaxant properties. Medicina (Kaunas, Lithuania). 2020; 56(3): 131. DOI: 10.3390/medicina56030131.


Neupane B., Sydykov A., Pradhan K. et al. Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice. Respiratory Research. 2020; 21(1): 136. DOI: 10.1186/s12931-020-01394-0.


Domvri K., Petanidis S., Anestakis D. et al. Exosomal lncRNA PCAT-1 promotes Kras-associated chemoresistance via immunosuppressive miR-182/miR-217 signaling and p27/CDK6 regulation. Oncotarget. 2020; 11(29): 2847-2862. DOI: 10.18632/oncotarget.27675.


Tsiouda T., Sardeli C., Porpodis K. et al. Sex differences and adverse effects between chemotherapy and immunotherapy for non-small cell lung cancer. Journal of Cancer. 2020; 11(11): 3407-3415. DOI: 10.7150/jca.40196.


Shi D., Li F., Wang K. et al. The development of bronchoscopy in China: A national cross-sectional study. Journal of Cancer. 2020; 11(19): 5547-5555. DOI: 10.7150/jca.47183.


Wygrecka M., Kosanovic D., Kwapiszewska G., Preissner K.T. Editorial: Multitasking Biomolecules in Human Pathologies: Known Players on Their Unexpected Journeys. Frontiers in Medicine. 2020; Vol.7: 478. DOI: 10.3389/fmed.2020.00478.

63. Domvri K., Petanidis S., Zarogoulidis P. et al. Treg-dependent immunosuppression triggers effector T cell dysfunction via the STING/ILC2 axis. Clinical Immunology. 2021; Vol.222: 108620. DOI: 10.1016/j.clim.2020.108620

64. Karnati S., Seimetz M., Kleefeldt F. et al. Chronic Obstructive Pulmonary Disease and the Cardiovascular System: Vascular Repair and Regeneration as a Therapeutic Target. Frontiers in Cardiovascular Medicine. 2021; Vol.8: 649512. DOI: 10.3389/fcvm.2021.649512.

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