Репозиторий Университета

Год публикации: Все года 2018 2019 2020

Название	Дата публикации	Коллектив авторов	Журнал	DOI	Индекс цитирования	Ссылка на источник
The prognostic role of circulating tumor cells (CTCs) in lung cancer Circulatingtumorcells Liquidbiopsy Lungcancer NSCLC SCLC	14.08.2018	Kapeleris J. Kulasinghe A. Warkiani M. Vela I. Kenny L. O'Byrne K. Punyadeera C.	Frontiers in Oncology		12	Ссылка © 2018 Kapeleris, Kulasinghe, Warkiani, Vela, Kenny, O'Byrne and Punyadeera. Lung cancer affects over 1. 8 million people worldwide and is the leading cause of cancer related mortality globally. Currently, diagnosis of lung cancer involves a combination of imaging and invasive biopsies to confirm histopathology. Non-invasive diagnostic techniques under investigation include "liquid biopsies" through a simple blood draw to develop predictive and prognostic biomarkers. A better understanding of circulating tumor cell (CTC) dissemination mechanisms offers promising potential for the development of techniques to assist in the diagnosis of lung cancer. Enumeration and characterization of CTCs has the potential to act as a prognostic biomarker and to identify novel drug targets for a precision medicine approach to lung cancer care. This review will focus on the current status of CTCs and their potential diagnostic and prognostic utility in this setting. Читать тезис
Melanoma circulating tumor cells: Benefits and challenges required for clinical application Biomarker Cancer Circulatingtumorcells Liquidbiopsy Melanoma	28.06.2018	Marsavela G. Aya-Bonilla C. Warkiani M. Gray E. Ziman M.	Cancer Letters		4	Ссылка © 2018 The implementation of novel therapeutic interventions has improved the survival rates of melanoma patients with metastatic disease. Nonetheless, only 33% of treated cases exhibit long term responses. Circulating tumor cell (CTC) measurements are currently of clinical value in breast, prostate and colorectal cancers. However, the clinical utility of melanoma CTCs (MelCTCs) is still unclear due to challenges that appear intrinsic to MelCTCs (i.e. rarity, heterogeneity) and a lack of standardization in their isolation, across research laboratories. Here, we review the latest developments, pinpoint the challenges in MelCTC isolation and address their potential role in melanoma management. Читать тезис

Репозиторий Университета

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