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Ссылка на источник |
Possible Ways of Studying Pharmacokinetic Parameters of Calcium Preparations
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01.06.2018 |
Eremenko N.
Shikh E.
Serebrova S.
Goryachev D.
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Pharmaceutical Chemistry Journal |
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Ссылка
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Issues pertaining to determination of the pharmacokinetic parameters of calcium preparations are examined using their comparative bioavailability as an example. Pharmacokinetic parameters of calcium such as area under the concentration—time curve (AUC) and maximum concentration (Cmax) are calculated considering the background calcium contents in volunteers. Calcium excretion with urine is assessed as clearance of creatinine, a calcium elimination factor. The dynamics of the content of parathormone (PTH), the main hormone regulating calcium homeostasis, are studied. The results can be used to plan clinical trials for assessing the pharmacokinetics of drug analogs of endogenous compounds.
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Clinical pharmacological approaches in the study of pharmacokinetic parameters of drugs - Analogs of endogenous calcium-containing compounds
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01.01.2018 |
Eremenko N.
Shikh E.
Serebrova S.
Goryachev D.
Prokof'Ev A.
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Eksperimental'naya i Klinicheskaya Farmakologiya |
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0 |
Ссылка
© 2018 Izdatel'stvo Meditsina. All rights reserved. Results of studying the comparative bioavailability of pharmaceutical preparations - alternative analogs of endogenous compounds containing calcium and colecalciferol are presented. The drug concentrations were recalculated with allowance for the endogenous calcium level, in accordance with the relevant normative guidelines. The standard methodology of bioequivalence studies can be used to evaluate the quality of reproduced calcium preparations, taking into account low values of intra-individual variability of pharmacokinetic parameters.
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