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Inflammasomal diseases
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01.03.2018 |
Pirozhkov S.
Litvitskiy P.
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Immunologiya |
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0 |
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© 2018 Meditsina Publishers. All rights reserved. NLR family of receptors are important members of the innate immunity that respond to exogenous pathogens and endogenous danger signals. Activation of NLR leads to formation of a multimolecular complex called an inflammasome. This complex is used to drive the processing and release of pro-inflammatory cytokines IL-1β and IL-18. Defects in regulation of an inflammasome activation underlie the development of a series of autoinflammatory diseases such as cryopyrin-associated periodic syndromes, familial Mediterranean fever and others. In this review we discuss forms of pathology associated with mutations and gene polymorphism of inflammasomes NLRP3, NLRP1, NLRС2 and NLRP12.
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