Репозиторий Университета

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Название	Дата публикации	Коллектив авторов	Журнал	DOI	Индекс цитирования	Ссылка на источник
Paip2 is localized to active promoters and loaded onto nascent mRNA in Drosophila mRNA nucleus Paip2 promoter transcription	18.07.2018	Kachaev Z. Lebedeva L. Kozlov E. Toropygin I. Schedl P. Shidlovskii Y.	Cell Cycle		1	Ссылка © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Paip2 (Poly(A)-binding protein–interacting protein 2) is a conserved metazoan-specific protein that has been implicated in regulating the translation and stability of mRNAs. However, we have found that Paip2 is not restricted to the cytoplasm but is also found in the nucleus in Drosophila embryos, salivary glands, testes, and tissue culture cells. Nuclear Paip2 is associated with chromatin, and in chromatin immunoprecipitation experiments it maps to the promoter regions of active genes. However, this chromatin association is indirect, as it is RNA-dependent. Thus, Paip2 is one more item in the growing list of translation factors that are recruited to mRNAs co-transcriptionally. Читать тезис