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Antiviral therapy of hepatitis C with 1 genotype after liver transplantation
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01.01.2018 |
Tsiroulnikova O.
Umrik D.
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Vestnik Transplantologii i Iskusstvennykh Organov |
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0 |
Ссылка
© 2018 Russian Transplant Society. All rights reserved. Chronic HCV infection is the leading cause of liver transplantation in adults in developed countries. Unfortunately, the reinfection of the graft inevitably occurs in all patients with persistent replication of the virus. Against the background of the necessary immunosuppressive therapy, the progression of the disease accelerates, leading to rapid decompensation of the liver. Antiviral therapy significantly improves the results of transplantation, but the use of standard interferon-based regimens is associated with low efficacy (no more than 30% for the most common 1 genotype of the virus) and poor tolerance. The article describes new interferon-free oral regimens used to treat the recurrence of HCV infection of 1 genotype.
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Experience of effective antiviral therapy in a liver recipient with recurrent HCV infection genotype 1
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01.01.2018 |
Umrik D.
Tsiroulnikova O.
Miloserdov I.
Latypov R.
Egorova E.
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Vestnik Transplantologii i Iskusstvennykh Organov |
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0 |
Ссылка
© 2018 Russian Transplant Society. All Rights Reserved. HCV infection is one of the most common causes leading to the development of terminal liver diseases – cirrhosis and hepatocellular carcinoma, the main treatment for which is orthotopic liver transplantation. However, with continued virus replication, 100% reinfection occurs, which leads to the rapid progression of cirrhosis of the graft and the loss of its function. Standard interferon-containing therapy is ineffective for HCV infection, especially genotype 1, both before and after transplantation, and also has a wide range of adverse events. The article presents the successful experience of treating the recurrence of HCV infection 1 genotype in a patient who underwent liver transplantation and several courses of ineffective antiviral therapy.
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