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Название |
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Ссылка на источник |
Analgesic Activity of a Polypeptide Modulator of TRPV1 Receptors
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01.06.2018 |
D’yachenko I.
Belous G.
Skobtsova L.
Zharmukhamedova T.
Palikov V.
Palikova Y.
D’yachenko E.
Kalabina E.
Rudenko V.
Andreev Y.
Logashina Y.
Kozlov S.
Yavorskii A.
Murashev A.
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Pharmaceutical Chemistry Journal |
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0 |
Ссылка
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. The activity of APHC2, a new polypeptide modulator of TRPV1 receptors that was isolated from Heteractis crispa, is studied. It was established that APHC2 possessed analgesic properties, did not disturb normal locomotor activity, and did not change body temperature and hemostasis of experimental animals. These attributes could be of great practical value for designing a new generation of efficacious analgesics. A brief increase of heart rate was observed during studies of the hemodynamic activity. Further investigation of the binding specifics of this polypeptide with TRPV1 receptors could open approaches to discovering other antagonists of these receptors.
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Prospects of a Search for Kappa-Opioid Receptor Agonists with Analgesic Activity (Review)
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01.01.2018 |
Zaitseva N.
Galan S.
Pavlova L.
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Pharmaceutical Chemistry Journal |
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0 |
Ссылка
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Current approaches to the search for new kappa-opioid receptor (κ-OR) agonists with potential analgesic activity are reviewed. Agents with peripheral activity and biased agonists are most promising for development. Signal events initiated by κ-OR activation are considered. Chemical structures of presently known κ-OR agonists are presented.
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