Репозиторий Университета

Год публикации: Все года 2018 2019 2020

Название	Дата публикации	Коллектив авторов	Журнал	DOI	Индекс цитирования	Ссылка на источник
Development of Dosage Forms Containing a Solid Dispersion of Diclofenac bioavailability diclofenac polyethyleneglycol-1500 soliddispersions solubility tablets	01.07.2018	Krasnyuk I. Ovsyannikova L. Stepanova O. Belyatskaya A. Grikh V. Kosheleva T. Skovpen Y. Kozin D.	Pharmaceutical Chemistry Journal		0	Ссылка © 2018, Springer Science+Business Media, LLC, part of Springer Nature. Technology development for solid dosage forms with a solid dispersion of diclofenac is a crucial problem in pharmaceutical science and practice. The goal of the work was science-based and experimental technology development for tablets containing a solid dispersion of diclofenac with improved biopharmaceutical indicators as an equivalent to the substance. The obtained granulates and tablets had indicators that met the corresponding standards of the Russian SP XIIIth Ed. Almost 100% of the diclofenac was released from the developed tablets. This was 1.3 times greater than from commercial tablets. The recommended shelf life under these conditions is two years. The proposed technology could not only increase the bioavailability of the slightly soluble non-salt form of diclofenac but also facilitate further development of new medicinal preparations with improved bioavailability. Читать тезис