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Ссылка на источник |
Novel Solid Dispersions Increasing the Solubility of Prothionamide
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01.12.2019 |
Krasnyuk I.
Beliatskaya A.
Krasnyuk I.
Stepanova O.
Galkina I.
Lutsenko S.
Litvinova T.
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BioNanoScience |
10.1007/s12668-019-00659-3 |
0 |
Ссылка
© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Water solubility of prothionamide and its solid dispersions with polyethylene glycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin was studied. The most promising results were obtained with the solid dispersion with polyvinylpyrrolidone, which provided a 2.6-fold general increase of drug’s solubility and about a 6-fold dissolution rate increase, the maximal values among the studied drug forms. The results of complex physicochemical studies suggested that the improved drug release was due to micronization and solubilizing action of the polymer. A principal factor was the destruction of the crystal lattice and formation of amorphous particles in the solid dispersion. The obtained data can be useful for the development of modified pharmaceutical forms of prothionamide with improved drug release profile.
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Development of Dosage Forms Containing a Solid Dispersion of Diclofenac
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01.07.2018 |
Krasnyuk I.
Ovsyannikova L.
Stepanova O.
Belyatskaya A.
Grikh V.
Kosheleva T.
Skovpen Y.
Kozin D.
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Pharmaceutical Chemistry Journal |
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0 |
Ссылка
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Technology development for solid dosage forms with a solid dispersion of diclofenac is a crucial problem in pharmaceutical science and practice. The goal of the work was science-based and experimental technology development for tablets containing a solid dispersion of diclofenac with improved biopharmaceutical indicators as an equivalent to the substance. The obtained granulates and tablets had indicators that met the corresponding standards of the Russian SP XIIIth Ed. Almost 100% of the diclofenac was released from the developed tablets. This was 1.3 times greater than from commercial tablets. The recommended shelf life under these conditions is two years. The proposed technology could not only increase the bioavailability of the slightly soluble non-salt form of diclofenac but also facilitate further development of new medicinal preparations with improved bioavailability.
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